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Är några andra risker associerade med H. pylori-infektion?

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Infektion med H. pylori förefaller vara associerad med ökad risk för magcancer och lymfom i mukosaassocierad lymfatisk vävnad (MALT-lymfom) [3,4].

Detta samband tros vara kausalt och en metaanalys av kohort- eller fallkontrollstudier drog slutstsen att infektion med bakterien är en riskfaktor för magcancer [5]. Sådan evidens ger stöd åt uppfattningen att det kan vara klokt att eradikera H. pylori hos asymtomatiska personer som konstateras vara infekterade med bakterien och som har en nära familjemedlem med magcancer i anamnesen [6,7]

 

Referenser:

  1. Befrits R, Sjöstedt S, Tour R, Leijonmarck CE, Hedenborg L, Backman M; Stockholm United Study Group for Helicobacter Pylori. Long-term effects of eradication of Helicobacter pylori on relapse and histology in gastric ulcer patients: a two-year follow-up study. Scand J Gastroenterol 2004;39(11):1066-72.
  2. Peura D, Graham D. Helicobacter pylori: consensus reached: peptic ulcer is on the way to becoming an historic disease. Am J Gastroenterol 1994;89:1137–39.
  3. Rokkas T, Wotherspoon A. Carcinogenesis. Curr Opin Gastroenterol 1999;15 Suppl 1:S23–8.
  4. Asaka M, Dragosics B. Helicobacter pylori and gastric malignancies. Helicobacter 2004;9 Suppl 1:35–41.
  5. Huang J, Sridhar S, Chen Y, Hunt R. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998;114:1169–79.
  6. Malfertheiner P, Mégraud F, O'Morain C, Hungin P, Jones R, Axon A et al. European Helicobacter Pylori Study Group. Current concepts in the management of H. pylori infection – The Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther 2002;16:167–80.
  7. Hunt R, Fallone C, Veldhuyzen van Zanten S, Sherman P, Smaill F, Flook N, et al. Canadian Helicobacter Study Group Consensus Conference: Update on the management of Helicobacter pylori – an evidence-based evaluation of six topics relevant to clinical outcomes in patients evaluated for H. pylori infection. Can J Gastroenterol 2004;18:547–54.
  8. Miehlke S, Bayerdörffer E, Lehn N, Mannes G, Sommer A, Hochter W, et al. Two year follow up of duodenal ulcer patients treated with omeprazole and amoxicillin. Digestion 1995;56:187–93.
  9. Axon AT, O’Morain CA, Bardhan KD, Crowe JP, Beattie AD, Thompson RP et al. Randomised double-blind controlled study of recurrence of gastric ulcer after treatment for eradication of Helicobacter pylori infection. BMJ 1997;314:565–8.
  10. Bell G, Powell U. Helicobacter pylori reinfection after apparent eradication – the Ipswich experience. Scand J Gastroenterol 1996;31 Suppl 215:96–104.
  11. European Helicobacter Pylori Study Group. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. Gut 1997;41:8–13.
  12. Howden C. For what conditions is there evidence-based justification for the treatment of H. pylori infection? Gastroenterology 1997;113 Suppl:S107–12.
  13. Lam S, Talley N. Helicobacter pylori consensus: Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection. J Gastroenterol Hepatol 1998;13:1–12.
  14. Hunt R, Thomson A. Canadian Helicobacter pylori consensus conference. Can J Gastroenterol 1998;12:31–41.
  15. Rubin G, Meineche-Schmidt V, Roberts A. The management of Helicobacter pylori infection in primary care: guidelines from the ESPCG. Eur J Gen Pract 1999;5:98–104.

Senast uppdaterad: 2009-04-01

 
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